Author: BOC Sciences

Isotopic labeling is a powerful technique used in various scientific fields, including chemistry, biology, and environmental science. By incorporating stable isotopes into molecules, researchers can trace metabolic pathways, study reaction mechanisms, and investigate molecular structures. This article explores four commonly used isotopic labels: Carbon-13 (¹³C), Oxygen-18 (¹⁸O), Deuterium (²H), and Nitrogen-15 (¹⁵N), highlighting their applications…

In recent years, Proteolysis-Targeting Chimeras (PROTAC) has become a frontier in the field of chemical biology and drug discovery by its unique event-driven mechanism of action, which breaks through the dependence of traditional small-molecule inhibitors on the “druggable target”. It has become a frontier in chemical biology and drug discovery. In this paper, we will…

Currently clinically used ADCs rely in most cases on efficient internalization and intracellular lysosomal transport for bio-cleavage of the linker and thus release of the drug. In addition, the cleaved drug must escape from the lysosome to achieve its therapeutic effect. However, not all tumor antigens ensure efficient ADC treatment as described above, especially in…

In the realm of pharmaceuticals and drug delivery systems, liposomes have emerged as a pivotal technology for enhancing the bioavailability and therapeutic efficacy of various compounds. As researchers and pharmaceutical companies strive to optimize drug delivery mechanisms, formulation solutions incorporating advanced liposomal technologies have proven to be invaluable. This article explores various innovative formulation solutions…